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For laboratory research use only — not for human or veterinary use

ReferenceMetabolic & incretin research

Retatrutide

LY3437943 · triple agonist · GGG agonist

Investigational triple GLP-1/GIP/glucagon receptor agonist studied in multi-receptor metabolic research.

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About Retatrutide

Retatrutide is a single-molecule triple agonist engineered to activate the GLP-1, GIP and glucagon receptors simultaneously. In laboratory and preclinical metabolic research it is used as a reference agonist for studying combined incretin-and-glucagon receptor signaling, energy expenditure and lipid handling. TagPep supplies retatrutide strictly as a research-use-only reference material.

Mechanism studied in research

Balanced agonism at three class-B GPCRs — GLP-1R and GIPR (incretin axis) plus GCGR (glucagon axis) — a combination studied for additive effects on substrate metabolism and energy expenditure in model systems.

Areas of research investigation

  • Multi-receptor incretin signaling assays
  • Energy-expenditure and thermogenesis models
  • Hepatic lipid-metabolism research
  • Comparative agonist potency studies

Laboratory handling

Supplied lyophilized. Research protocols typically reconstitute with bacteriostatic or sterile water and store the solution refrigerated (2–8 °C), with the lyophilized powder held frozen and protected from light.

Comparisons

Retatrutide vs Tirzepatide Retatrutide vs Semaglutide

Retatrutide research FAQ

Is retatrutide available to order for research?

Yes. TagPep stocks a 60 mg retatrutide research vial with a batch-linked Certificate of Analysis. It is sold for laboratory research use only and is not for human or veterinary use.

What makes retatrutide different from dual agonists?

Retatrutide adds glucagon-receptor (GCGR) agonism to the GLP-1/GIP incretin activity studied in dual agonists such as tirzepatide, which is why it is described as a triple agonist in the research literature.

Research use only. Retatrutide is supplied as a laboratory reference material for in-vitro and research applications. It is not a drug, supplement or medical product, and is not intended for human or veterinary use, consumption, or clinical application.